Pine Bluffs is an agricultural community located in Eastern Laramie County, on the western edge of the semi-arid High Plains 5000 to 5400 feet above sea level. Crops and animals that are raised here are alfalfa, amaranth, barley, dry edible beans, corn, grass hay, grass seed, millet, oats, potatoes, sunflowers, sugar beets turnips, trees, wheat, cattle, sheep, commercial and custom cattle feeding, commercial and custom sheep feeding, farrow to finish hog operations, ostrich, camel, llamas, horses, mules, and donkeys

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Manufacturing in Pine Bluffs includes metal fabrications, full service machine shop, and a saddle shop.

Retail businesses include antiques, appliances, auto parts, computer equipment, groceries, hardware, hair products, home furnishings, prescription drugs, ropes.

Service businesses include accounting, banking, restaurants, car care, computer repair, computer programming, entertainment, farming, motel, hair care, RV-hookups and campground.

Home-based businesses include day care, sewing, tie dying, quilting, and wood crafts.

Senior services: Senior Center serves congregate meals Monday through Friday 11:30 - 12:30 PM. Carryout meals and home delivered meals are also offered. Center provides seniors with transit.